Development of reverse phase HPLC method for simultaneous estimation of quetiapine fumarate and curcumin in nano structured lipid carrier formulations
نویسندگان
چکیده
The present work was aimed with the objective of developing simple, precise and sensitive high performance liquid chromatographic method for simultaneous estimation quetiapine fumarate curcumin to execute developed in both drugs nanostructured lipid carrier formulations. carried out using various solvents, buffers, at different flow rates complete separation drugs. Using ICH guidelines, validated. After trials conditions were optimized. possible phenomenex kinetex XB-C18 100 A analytical column (3.5 μm, 4.6 mm × 150 mm) methanol: water 70:30 v/v as a mobile phase, rate 1.0 mL/min. Sample 200 μL injected chromatogram recorded 290 nm triplicates. absorption maximum found be nm, whereas possess maxima 421 nm. is when estimated particular single wave length. peak response which has been fixed analysis.
منابع مشابه
development and implementation of an optimized control strategy for induction machine in an electric vehicle
in the area of automotive engineering there is a tendency to more electrification of power train. in this work control of an induction machine for the application of electric vehicle is investigated. through the changing operating point of the machine, adapting the rotor magnetization current seems to be useful to increase the machines efficiency. in the literature there are many approaches wh...
15 صفحه اولRp-hplc Method for the Simultaneous Estimation of Atrovastatin and Losartan in Pure and Tablet Formulations
The combination of Atorvastatin and Losartan was used in the management of Hypertension. The present work was focused on the development of RP-HPLC method for the estimation of Atorvastatin and Losartan in binary mixtures by internal standard method. The separation was performed on LUNA C18 column at 238 nm by isocratic elution using Telmisartan as internal standard. Methanol and phosphate buff...
متن کاملStability-Indicating RP-HPLC Method for the Simultaneous Estimation of Doxofylline and Terbutalinesulphate in Pharmaceutical Formulations
An isocratic, stability-indicating, reversed-phase high-performance liquid chromatography (RP-HPLC) method was developed for the quantitative determination of doxofylline and terbutaline sulphate, used for the treatment of respiratory problems. The chromatographic separation was achieved on a Zorbax-SB Phenyl 250 × 4.6mm × 5 μm column with the mobile phase consisting of a mixture of 25 mM ammon...
متن کاملPotentiometric Determination of Quetiapine Fumarate in Pharmaceutical Formulations
Quetiapine (QTF) is a potent serotonin and dopamine receptor antagonist used to treat major depressive disorders and schizophrenia. A simple, precise, accurate and costeffective titrimetric method for the determination of QTF in bulk drug and in its dosage forms has been developed and validated. The method is based on the potentiometric titration of QTF in glacial acetic acid with acetous perch...
متن کاملDevelopment of an RP-HPLC-UV method for simultaneous detection of nimodipine and its metabolite in cerebrospinal fluid of rat
A rapid, simple and reproducible HPLC method was developed and validated for the analysis of nimodipine (NM) and/or its metabolite, oxidized nimodipine (OX–NM) in rat cerebrospinal fluid (CSF) and artificial CSF. The NM and OX–NM were eluted in less than 10 min with no interferences from the endogenous CSF peaks. Analysis was carried out on a Eurospher Performance (RP-C18, 250 × 4.6 mm) column ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Health Sciences (IJHS)
سال: 2022
ISSN: ['2550-6978', '2550-696X']
DOI: https://doi.org/10.53730/ijhs.v6ns6.12752